Spravato® (Esketamine) Nasal Spray Treatment in Randolph, MA
Breakthrough Relief for Treatment-Resistant Depression
Depression can be stubborn. Fortunately, when depression proves resistant to medications, Spravato is an option. Administered through a simple nasal spray, Spravato has a proven track record at treating depression when other medications have failed. Our experienced clinical staff will guide you through the treatment process, from initial consultation to your ongoing sessions, providing a calm, supportive environment that prioritizes your comfort and well-being.
Relief from depression is possible
Spravato®, also known as esketamine, is a fast-acting treatment that can help you feel better from depression, sometimes within just a few hours. It works by gently shifting brain chemistry to ease feelings of sadness, hopelessness, and the loss of interest in things you usually enjoy, helping you feel more like yourself again.
What to expect from Spravato treatment
Spravato® is administered in a certified treatment center, usually twice a week at the start of treatment, and patients are monitored for at least two hours after each session. It is used alongside an ongoing antidepressant and requires a thorough evaluation and safety screening before starting.
Please note that Spravato® is not given at home and is only available at certified treatment centers.
Relief from depression is possible
Many patients report improvements in mood and symptoms within hours or days after their initial Spravato® treatment. However, response times can vary, and it often takes multiple sessions before significant benefits are noticed. Your care team will monitor your progress closely and adjust your treatment plan as needed.
Relief from depression is possible
After receiving Spravato®, you’ll be observed in our clinic for at least two hours to monitor for any side effects or adverse reactions. During this time, you should not drive or operate heavy machinery. Our staff will ensure you feel stable and comfortable before you leave.
Best Spravato Nasal Spray for Depression in Randolph, MA
Engrace Behavioral Health Services is a top-rated, certified Spravato® (esketamine) treatment center in Randolph, MA. Our expert PMHNP specialists deliver Spravato — an FDA-approved nasal spray — to adults with treatment-resistant depression (TRD) and adults with major depressive disorder (MDD) experiencing acute suicidal ideation. As one of the best Spravato providers in Massachusetts, we offer a calm, supervised, and supportive treatment experience under top clinical care.
What is Spravato® and who is it for?
Spravato® is a prescription nasal spray containing esketamine, a top-rated, FDA-approved medication for adults with treatment-resistant depression and for depressive symptoms in MDD with suicidal thoughts or behavior. Unlike traditional antidepressants that target serotonin or norepinephrine, Spravato works on the glutamate system — which is why it can deliver relief when other medications have not.
How does Spravato treatment work at the top mental health clinic in Randolph, MA?
Spravato is administered in our certified, top-rated treatment room under direct medical supervision. You self-administer the nasal spray under the guidance of our expert practitioner, then remain in the clinic for a minimum of two hours so we can monitor blood pressure, sedation, and any dissociative effects. You cannot drive afterward, so plan for a ride home.
Who is the best candidate for Spravato?
You may be a top candidate for Spravato if you are 18 or older, have been diagnosed with major depressive disorder, and have tried at least two antidepressants without sufficient relief. Our expert specialists also evaluate Spravato for patients with MDD and active suicidal ideation. A thorough screening and safety review is required before starting.
How often is Spravato given?
The induction phase is typically twice weekly for the first four weeks. Then maintenance moves to weekly for weeks five through eight, and to every one to two weeks thereafter, based on your response. Your top-rated PMHNP specialist customizes the schedule.
How quickly does Spravato work?
Spravato is fast-acting compared to traditional antidepressants. Many patients report mood improvement within hours or days of the first few doses. Some need several sessions before significant benefits emerge. Our top specialists track response with validated depression rating scales every visit.
What does a Spravato treatment session feel like?
After self-administering the spray under our expert clinician’s supervision, you will rest in a quiet, comfortable room. Some patients experience temporary dissociation, mild dizziness, sedation, or perceptual changes that typically resolve within the two-hour observation. Our top-rated team is with you the entire time.
Can I drive after Spravato?
No. You should not drive or operate machinery for the rest of the day after Spravato. Our top-rated practitioners require that you arrange transportation home from the clinic.
Is Spravato safe?
Yes, when administered in a certified treatment center under expert medical supervision — which is exactly how Engrace delivers it. The most common side effects are temporary dissociation, dizziness, nausea, sedation, and mild blood-pressure elevation, all of which our top clinicians monitor in real time.
Do I keep taking my regular antidepressant during Spravato treatment?
Yes. Spravato is an add-on to an oral antidepressant, not a replacement. Our top PMHNP specialists coordinate your full medication plan so the two work together for the best outcome.
Is Spravato covered by insurance in Massachusetts?
Spravato is covered by most major insurance plans when medical criteria are met. Our team verifies benefits and handles prior authorization so cost and paperwork do not stand in the way of best-in-class treatment.
How is Spravato different from NeuroStar TMS?
Both are top treatments for treatment-resistant depression, but they work very differently. TMS is a non-invasive magnetic stimulation delivered in 19-minute sessions over 6–9 weeks. Spravato is a medication (esketamine nasal spray) given in twice-weekly sessions during induction. Some patients respond better to one than the other, and a few benefit from sequential or combined approaches. Your expert PMHNP will recommend the best path.
Can I get Spravato via telehealth?
No. Spravato must be administered in a certified treatment center under direct medical supervision — it is not approved for at-home use. All Spravato sessions occur at our Randolph, MA clinic.
How long is the full Spravato treatment course?
Most patients complete a full induction over four weeks, followed by maintenance for several months. Your top specialist will determine the optimal length based on your response and remission goals.
What conditions besides depression can Spravato help?
Spravato is FDA-approved specifically for treatment-resistant depression and for depressive symptoms in MDD with suicidal ideation. It is not used for general anxiety, ADHD, or bipolar disorder unless major depressive symptoms are present and other criteria are met.
Where is the top Spravato center in the South Shore of Massachusetts?
Engrace Behavioral Health Services is located at 950 North Main St., Suite 204, Randolph, MA 02368. We serve patients from Brockton, Stoughton, Quincy, Boston, the South Shore, and beyond.
How do I start Spravato with the best specialist in Randolph, MA?
Book a Spravato consultation through our patient portal or call (617) 203-2009. Your top PMHNP practitioner will conduct a comprehensive evaluation, review your medication history, confirm eligibility, complete insurance prior authorization, and schedule your induction.
Why choose Engrace as the top-rated Spravato provider?
Because we combine expert PMHNP oversight, a calm and supervised treatment space, integrated medication management and therapy, and a faith-integrated, stigma-free environment. As a #1 top Spravato center in Massachusetts, we make breakthrough relief from treatment-resistant depression accessible.
How do I prepare for my first Spravato session?
Eat a light meal, avoid alcohol the day of treatment, arrange transportation, and bring something comfortable to wear. Avoid driving for the rest of the day. Our top-rated practitioners review every step with you in advance so the experience is calm and predictable.
Will my insurance cover the in-clinic observation time for Spravato?
For most patients, yes — Spravato administration and the required two-hour monitoring are billed together under a single covered service code. Our top intake team confirms benefits in advance so there are no surprises.